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Professor Yoshito Kumagai visited School of Public Health, Zhejiang University

Date:2019-01-17 10:58:43VisitCount:775

On January 14, 2019, Yoshito Kumagai, a professor from Environmental Biology Laboratory, School of Medicine at National University of Tsukuba, Japan, visited the School of Public Health, Zhejiang University and delivered a wonderful academic lecture in the Medical Research Conference Room. Professor Yoshito Kumagai worked as a member of the Japanese Society of Toxicology and served as the chairman of several major international toxicological conferences from 2009-2016, and member of the Nitric Oxide Society of Japan and the American Society of Toxicology. He also serves as the associate editor for Toxicological Sciences and Journal of Toxicological Sciences. His research work is mainly focused on toxicity and metabolism of environmental electrophiles in vivo and in vitro. He has published more than 150 high quality papers in Nat. Commun, Nat. Chem. Biol, PNAS, etc.

 

Prof. Kumagai's speech is entitled “Unique adaptive response to electrophilic stress” and hosted by Professor Naranmandura Hua. Prof. Kumagai introduced the double-edged effect of environmental electrophiles from the definition of RSS (reactive sulfur species). He indicate that high-dose exposure of electrophiles could attack all proteins sulfydryl indiscriminately and induce cytotoxicity, while low dose exposure could selectively activates low pKa sensor proteins, then promotes downstream protein transcription and protects against the stress.

 

At the end of the speech, Prof. Kumagai, Prof. CHEN Guangdi, Prof. Naranmandura and the participants had a hot discussion on how to make the balance of electrophiles in vivo. Professor Kumagai pointed out that everything has its double-edged effect, so we must find out a balanced point, avoid its harmful effects, and make a good use of its advantages to contribute to human health. Finally, he also introduced their team, shared their academic achievements and successful experience.

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